Among the prizes he has received for his works are the City of Stuttgart Composition Prize (1993), the Busoni Award for Composition from the Akademie der Künste Berlin (1996), the Vienna International Composition Prize (2004), the Ernst Krenek Prize of the City of Vienna (2006), and the Grant in aid Ernst-von-Siemens-Musikstiftung Munich (2010).

His works have been featured at festivals such as the Festival d’Automne à Paris, Wien Modern, Ars Musica Bruxelles, Donaueschinger Musiktagen, Wittener Tagen für neue Kammermusik, Musica Viva München, Huddersfield Contemporary Music Festival, and broadcasted by the most important radios (BBC, RF, R4A, WDR, SDR, BRD, NDR, ORF, DRS, RCE, JR).

He receives regular invitations to give seminars and composition courses (IEMA-International Ensemble Modern Academy Frankfurt , Conservatoire Paris, Conservatorium Amsterdam, Musikuniversität Wien, Harvard University Boston, Columbia University N.Y., Summer courses Darmstadt 2010, Impulse Academy Graz 2011, Tzlil Meducan Israel 2011, MCME Intern. Academy Russia 2011, PAS-E Venice, Summer courses Darmstadt 2012) .

Pierluigi Billone has been guest professor for composition at the Music University Graz untill 2012.

His music appears on the CD labels Kairos, Stradivarius, Col-legno, Durian, EMSA, ein_klang.